Crossroads Guitar Festival - a music festival and benefit concert first held in 2004. The festival is held in favor of Eric Clapton-based drug treatment center Crossroads Centre. As in 2007, the festival was held again at Toyota Park in Bridgeview, Illinois, June 26, 2010, and became the next holiday blues.

Disc 1: Bill Murray Introduction with Eric Clapton
1. Sonny Landreth with Eric Clapton - Promise Land
2. Sonny Landreth - Z Rider
-SLIDE GUITAR
3. Robert Randolph and the Family Band - Traveling Shoes
4. Joe Bonamassa & Pino Daniele with Robert Randolph - Going Down
-Bill Murray introduces Robert Cray
5. Robert Cray, Jimmie Vaughn & Hubert Sumlin - Killing Floor
6. Jimmie Vaughn, Robert Cray & Hubert Sumlin - Six Stings Down
-TEXAS BLUES
-Bill Murray introduces ZZ Top
7. ZZ Top - Waiting For the Bus
8. ZZ Top - Jesus Just Left Chicago
9. Doyle Bramhall II - Gypsy Blood
10. Doyle Bramhall II - In My Time Of Dying
11. Gary Clark Jr - Bright Lights
12. Sheryl Crow with Derek Trucks, Susan Tedeschi, Doyle Bramhall II & Gary Clark Jr - Long Road Home
13. Sheryl Crow with Eric Clapton, Doyle Bramhall II & Gary Clark Jr - Our Love Is Fading
14. Bert Jansch - Blackwaterside
15. Stefan Grossman with Keb Mo - Mississippi Blues
16. Stefan Grossman with Keb Mo - Roll 'N' Tumble
-COUNTRY MUSIC
-Bill Murray introduces Vince Gill
17. Vince Gill, Keb Mo, James Burton, Earl Klugh, Albert Lee - One More Last Chance
18. Vince Gill, James Burton, Albert Lee, Keb Mo, Earl Klugh - Mystery Train
19. Vince Gill, Keb Mo, Albert Lee, James Burton, Earl Klugh & Sheryl Crow - Lay Down Sally
20. Earl Klugh - Angelina
21. Earl Klugh - Vonetta
-Bill Murray introduces John Mayer
22. John Mayer Trio - Who Did You Think I Was
23. John Mayer Trio - Ain't No Sunshine

Disc 2: Bill Murray introduces Derek Trucks
1. Derek Trucks & Susan Tedeschi Band - Midnight In Harlem
2. Derek Trucks & Susan Tedeschi Band featuring Warren Haynes - Comin' Home
3. Warren Haynes - Soulshine
4. David Hidalgo and Cesar Rojas featuring Derek Trucks - Don't Keep Me Wondering
5. Derek Trucks & Susan Tedeschi Band featuring Warren Haynes, David Hidalgo, Cesar Rojas, Chris Stainton - Space Captain
-Bill Murray introduces Buddy, Jonny & Ronnie
6. Buddy Guy with Jonny Lang & Ronnie Wood - Five Long Years
7. Buddy Guy with Jonny Lang & Ronnie Wood - Miss You
-Bill Murray introduces Jeff Beck
8. Jeff Beck - Hammerhead
9. Jeff Beck - Nessun Dorma
-Bill Murray introduces Eric Clapton
10. Eric Clapton - Crossroads
11. Citizen Cope & Eric Clapton - Hands of the Saints
12. Eric Clapton - I Shot The Sheriff
13. Eric Clapton & Jeff Beck - Shake Your Money Maker
14. Eric Clapton & Steve Winwood - Had To Cry
15. Eric Clapton & Steve Winwood - Voodoo Chile
16. Eric Clapton & Steve Winwood - Dear Mr. Fantasy
-Bill Murray introduces BB King
17. Finale: Eric Clapton, BB King, Robert Cray, Jimmie Vaughn, Joe Bonamassa, and others - The Thrill Is Gone